I too have had lifelong problems with IBS with constipation. I have been told numerous times : fiber, fluids, exercise. If it were that easy, I wouldn’t have a problem. I finally found a doctor who experiences the same problem and she suggested Amitiza. I did a lot of research and was hesitant to try it, but It is the only thing that has ever worked consistently for me. Fortunately I do not have any of the side effects that some have. Hope this will help some who really have done everything and still have problems.