Should I move across the country alone and “start my life over?”

My background: I’ll be 28-years-old in one month. I am not close with my extended and immediate family. I’ve lived 4 hours away from my hometown for the past 9 years. I’m also estranged from my biological mother due to her lifelong drug problems, habit of disappearing from my life, and borderline abusive behavior.

In the past three years:
-I was engaged and my fiancé unexpectedly left me in the middle of our wedding planning process.
-I tried to date (online and through some friends). I have dated about 28 different men and unfortunately nothing has worked out. I’m currently seeing someone, but I don’t feel confident in our relationship making it through the long haul.
-I was diagnosed with a chronic illness, but lately it has (thankfully) been manageable. I work from home remotely full time.
-I’m in the process of re-homing my dog (this is a whole different story in another thread).
-My close friends are in relationships/engaged/married/co-habitating/homeowners/and parents. I feel very sad that my life doesn’t relate to theirs and vice versa.
-I live with two friends (they’re in a relationship and have been for 5 years). Lately, I’ve been resenting them. I recognize this is my issue- not theirs. They haven’t really done anything wrong. I feel resentful because they do not seem to understand why I’m sad. They also take an approach of “try harder” when it comes to all of my problems. Do I want better health? Try harder. Do I want a boyfriend? Try harder. I’ve been trying for the past three years and still feel that I’m stuck at the starting line.

I’ve been seriously considering moving across the country to California and starting over. I feel like I don’t like this life anymore. I want a new one and I don’t know how to else to do that besides uprooting my life and having a completely clean slate to work off of.